Steve Martin (Tom Baker), Bonnie Hunt (Kate Baker), Piper Perabo (Nora Baker-McNulty), Eugene Levy (Jimmy Murtaugh), Tom Welling (Charlie Baker), Hilary Duff (Lorraine Baker), Jaime King (Anne Murtaugh), Carmen Electra (Sarina Murtaugh), Taylor Lautner (Elliott Murtaugh), Alyson Stoner (Sarah Baker), Jacob Smith (Jake Baker), Kevin Schmidt (Henry Baker), Liliana Mumy (Jessica Baker), Morgan York (Kim Baker), Forrest Landis (Mark Baker), Blake Woodruff (Mike Baker), Brent Kinsman (Nigel Baker), Shane Kinsman (Kyle Baker), Alexander Conti (Kenneth Murtaugh), Kevin G. Schmidt (Henry Baker), Shawn Roberts (Calvin Murtaugh), Jonathan Bennett (Bud McNulty), Peter Keleghan (Mike Romanow), Sam Kalilieh (Arzt), Melanie Tonello (Becky Murtaugh), Robbie Amell (Daniel Murtaugh), Courtney Fitzpatrick (Lisa Murtaugh), Madison Fitzpatrick (Robin Murtaugh), William Copeland (Commodore), Damon Runyan (Tennisprofi), Graham Losee (Platzanweiser), Seth Howard (Muschelkellner), Matthew Knight (Kind im Theater), Lee MacDougall (Mr. Doobner), Jenny Parsons (Mrs. Doobner), Dylan Rosenthal (älterer Doobner-Sohn), Haylee Wanstall (Doobner-Tochter), Ely Henry (jüngerer Doobner-Sohn), Tre Smith (Wachmann), Adam Shankman (Muschelkoch), Shawn Levy (Krankenhausarzt)