Will Smith (Captain Steven 'Steve' Hiller), Bill Pullman (Präsident Thomas J. Whitmore), Jeff Goldblum (David Levinson), Mary McDonnell (First Lady Marilyn Whitmore), Mae Whitman (Patricia Whitmore), Judd Hirsch (Julius Levinson), Robert Loggia (General William Grey), Randy Quaid (Russell Casse), Margaret Colin (Constance 'Connie' Spano), Vivica A. Fox (Jasmine Dubrow), Adam Baldwin (Major Mitchell), Bill Smitrovich (Captain Watson), Brent Spiner (Dr. Brackish Okun), Harry Connick Jr. (Captain Jimmy Wilder), Ross Bagley (Dylan), David Pressman (Whitmore's Helfer), Devon Gummersall (Philip), Frank Novak (Teddy), John Storey (Dr. Isaacs), Giuseppe Andrews (Troy), Harvey Fierstein (Marty Gilbert), James Duval (Miguel), James Rebhorn (Albert Nimziki), Leland Orser (Arzthelfer), Lisa Jakub (Alicia), Kiersten Warren (Tiffany)