Jean Reno (Léon), Gary Oldman (Norman Stansfield), Natalie Portman (Mathilda), Danny Aiello (Tony), Peter Appel (Malky), Michael Badalucco (Mathildas Vater), Ellen Greene (Mathildas Mutter), Elizabeth Regen (Mathildas Schwester), Carl J. Matusovich (Mathildas Bruder), Willi One Blood (Mitarbeiter von Stansfield), Don Creech (2. Stansfield-Mann), Keith A. Glascoe (3. Stansfield-Mann), Randolph Scott (4. Stansfield-Mann), Eric Challier (Bodyguard-Chef), George Martin (Rezeptionist), Luc Bernard (Mickey), Maïwenn (Blondine), Stuart Rudin (Leons Taxifahrer), Kent Broadhurst (Polizist #1), Tommy Hollis (Polizist #2), Lucius Wyatt Cherokee (Tonto), Jessie Keosian (alte Dame), Frank Senger (Fatman), Abdul Hassan Sharif (Mathildas Taxifahrer), Peter Linari (Sicherheitsmann)