George Clooney (Daniel 'Danny' Ocean), Brad Pitt (Robert 'Rusty' Ryan), Matt Damon (Linus Caldwell / Lenny), Al Pacino (Willy Bank), Don Cheadle (Basher Tarr / Fender Roads), Bernie Mac (Frank Catton), Ellen Barkin (Abigail Sponder), Casey Affleck (Virgil Malloy), Scott Caan (Turk Malloy), Elliott Gould (Reuben Tishkoff), Shaobo Qin (Yen / Mr. Ding), Eddie Jemison (Livingston Dell), Andy García (Terry Benedict), Michael Mantell (Dr. Stan), Carl Reiner (Saul Bloom / Kensington Chub), Eddie Izzard (Roman Nagel), Olga Sosnovska (Debbie), Luis Chàvez (Nestor / Nestors Bruder), Armen Weitzman (Eugene), Julian Sands (Greco Montgomery), Vincent Cassel (François Toulour), Bob Einstein (Agent Caldwell), Oprah Winfrey (sie selbst), Ivar Brogger (Shuffle Royale VP), David Paymer (Five Diamond Juror (VUP))