Martin Freeman (Arthur Dent), Mos Def (Ford Prefect), Sam Rockwell (Zaphod Beeblebrox), Zooey Deschanel (Tricia 'Trillian' McMillan), Warwick Davis (Marvin), Bill Nighy (Slartibartfast), John Malkovich (Humma Kavula), Anna Chancellor (Questular Rontok), Dominique Jackson (Fook), Ian McNeice (Kwaltz), Garth Jennings (Frankie Mouse), Mark Smith (Pall Bearer), Jack Stanley (Lunkwill), Jason Schwartzman (Gag Halfrunt), Richard Griffiths (Jeltz), Stephen Fry (Erzähler), Thomas Lennon (Eddie der Computer)