Logan Lerman (Percy Jackson), Brandon T. Jackson (Grover Underwood), Uma Thurman (Medusa), Pierce Brosnan (Mr. Brunner / Chiron), Kevin McKidd (Poseidon), Jake Abel (Luke Castellan), Alexandra Daddario (Annabeth Chase), Sean Bean (Zeus), Steve Coogan (Hades), Rosario Dawson (Persephone), Catherine Keener (Sally Jackson), Melina Kanakaredes (Athene), Joe Pantoliano (Gabe Ugliano), Erica Cerra (Hera), Dylan Neal (Hermes), Chelan Simmons (Silena Beauregard), Maria Olsen (Mrs. Dodds), Serinda Swan (Aphrodite), Julian Richings (Fährmann), Stefanie von Pfetten (Demeter), Dimitri Lekkos (Apollo), Luke Camilleri (Dionysos)