Freddie Prinze jr. (Fred Jones), Sarah Michelle Gellar (Daphne Blake), Matthew Lillard (Shaggy Rogers), Linda Cardellini (Velma Dinkley), Seth Green (Patrick), Peter Boyle (Jeremiah Wickles), Tim Blake Nelson (Dr. Jonathan Jacobo), Alicia Silverstone (Heather), Zahf Paroo (Ned), Pat O'Brien (Pat O'Brien), Kwesi Ameyaw (Mann im Anzug), Emily Tennant (junge Daphne), Stephen E. Miller (C.L. Magnus), Karin Konoval (Aggie Wilkins), Colin Foo (Investor), Andrew McIlroy (Investor), Andrew Jackson (Man im Auto), Brenna O'Brien (Buttercup Scout), Chris Gauthier (Daphne's tätowierter Fan #1), Peter New (Daphne's tätowierter Fan #2)