Freddie Prinze jr. (Fred), Sarah Michelle Gellar (Daphne Blake), Matthew Lillard (Shaggy Rogers), Linda Cardellini (Velma Dinkley), Rowan Atkinson (Mondavarious), Isla Fisher (Mary Jane), Miguel A. Nunez jr. (Voodoo-Priester), Steven Grives (N' Goo Tuana), Sam Greco (Zarkos), Charles Cousins (Velmas Freund), Michala Banas (Carol), Jess Harnell (Kreatur), J.P. Manoux (Scrappy Rex), Kristian Schmid (Brad), Matt Lee (Tänzer), Frank Welker (Kreatur), Kym Jackson (Autogrammjägerin), Holly Brisley (Frau im Trainingsvideo), Andrew Bryniarski (Handlanger), Mark McGrath (Sugar Ray)