Chris Pine (Captain James 'Jim' T. Kirk), Idris Elba (Krall / Captain Balthazar Edison), Zachary Quinto (Commander Spock), Zoe Saldana (Lieutenant Nyota Uhura), Karl Urban (Dr. Leonard 'Pille' McCoy), Anton Yelchin (Fähnrich Pavel Chekov), John Cho (Lieutenant Hikaru Sulu), Deep Roy (Keenser), Sofia Boutella (Jaylah), Shohreh Aghdashloo (Commodore Paris), Joseph Gatt (Wissenschaftsoffizier), Melissa Roxburgh (Syl), Fiona Vroom (Mädchen vom Orion), Lydia Wilson (Kalara), Christian Sloan (Jae), Jason Matthew Smith (Hendorff), Ashley Edner (Natalia), Joe Taslim (Manas), Anthony Shim (Jin), Adam DiMarco (verletzter Senator), Priya Rajaratnam (Captain auf Nachtwache), Lia Lam (Brückenoffizier), Roxanne Fernandes (Brückenoffizierin), Polina Nikolai (Brückencrew), Rebecca Husain (Brückencrew)