Bruce Willis (John McClane), Timothy Olyphant (Thomas Gabriel), Justin Long (Matthew 'Matt' Farrell), Maggie Q (Mai Linh), Cliff Curtis (Miguel Bowman, FBI), Mary Elizabeth Winstead (Lucy Gennaro McClane), Kevin Smith (Frederick 'Warlock' Kaludis), Tim Russ (Chuck Summer), Cyril Raffaelli (Rand), Yorgo Constantine (Russo), Andrew Friedman (Casper), Chris Palermo (Del), Sung Kang (Raj), Zeljko Ivanek (Agent Molina), Christina Chang (Taylor), Jake McDorman (Jim), Rosemary Knower (Mrs. Kaludis), Allen Maldonado (Goatee), Jim Cantafio (Ladenbesitzer), Chris Ellis (Scalvino), Tony Colitti (Hazmat-Chefagent), Tim de Zarn (Polizist), Jonathan Sadowski (Trey), Regina McKee Redwing (Agentin), Gerald Downey (Agent), Kurt David Anderson (Miller)