Arnold Schwarzenegger (Terminator T-800), Jason Clarke (John Connor / T-3000), Emilia Clarke (Sarah Connor), Jai Courtney (Kyle Reese), J.K. Simmons (Detective O'Brien), Lee Byung Hun (T-1000), Courtney B. Vance (Miles Dyson), Michael Gladis (Lieutenant Matias), Sandrine Holt (Detective Cheung), Dayo Okeniyi (Danny Dyson), Afemo Omilami (Perry), Douglas M. Griffin (Garber), Gregory Alan Williams (Detective Harding), Kerry Cahill (Lieutenant Whitley), Kyle Russell Clements (Commander Pike Sumner), Otto Sanchez (Detective Timmons), Matty Ferraro (Agent Janssen), Matthew Smith (Alex / T-5000 / Skynet), Brett Azar (Junger Wächter / T-800), Aaron V. Williamson (Flüchtling / T-800), Kerry O'Malley (Kyles Mutter), Mark Adam (Kyles Vater), Teri Wyble (Mariam), Griff Furst (Burke), Thomas Francis Murphy (Obdachloser), Wayne Bastrup (Der junge O'Brien), Bryant Prince (Der junge Kyle Reese), Moses Munoz (Guerrilla Ramirez)